Patterning Interfaces Near the Atomic Limit: Lessons from the Cell Membrane
Shelley A. Claridge
Many applications in modern materials science require surfaces with embedded chemical information at scales < 10 nm, to control interactions with light for energy conversion, to direct the flow of electrons, or to induce molecular recognition with receptor protein complexes on cell surfaces. Lithographic patterning rapidly becomes more expensive at scales below 100 nm, and is limited in terms of the chemistry that can be patterned. Conversely, biology generates a spectacular diversity of chemical patterns at few-nm scales, to control chemical and mechanical circuits that are central to biological function. A fundamental transformation to the molecular constituents of cell membranes enables us to use them to pattern interfaces with resolution exceeding that available at cutting edge lithographic fabrication facilities. We describe technological applications of the powerful chemical control enabled by this approach, from templating inorganic nanowires to scaffolding cell growth.
现代材料科学的许多应用需要在材料表面嵌入小于10 nm的化学信息，以此来调控光能转换，导引电子流，以及诱导细胞表面的受体蛋白复合物进行分子识别。但如系小于100 nm的界面图，则印压技术成本激增，限制了该技术在化学信息布图方面的应用。与印压技术相对，为调控对生物功能至关重要的化学和机械反应，生物学衍生出了一系列惊人的纳米级化学图案。探索思路向细胞膜分子构架的根本性转变，使我们能够利用该构架创绘先进印压技术无法企及的界面图形。从无机金属线排布，到搭造细胞生长支架，我们已在多个科技领域描绘了这一强效化学调控技术。
Shelley Claridge received undergraduate degrees in mathematics and biochemistry from Texas A&M University, and subsequently worked as a software engineer for six years prior to completing a Ph.D. at UC Berkeley with Paul Alivisatos and Jean Fréchet. After a postdoctoral fellowship with Paul Weiss at UCLA, she joined the faculty at Purdue University in 2013, and was promoted to Associate Professor with tenure in 2019. Her research at Purdue has been recognized with Young Investigator awards from NSF, DARPA (2017 Young Faculty Award and 2019 DARPA Director’s Fellowship), 3M, and DuPont (one of 8 globally in 2016), as well as emerging investigator recognitions from ACS Nano, Journal of the American Chemical Society, Chemical Communications, Analytical Methods, and Analytical and Bioanalytical Chemistry. Work from her group has also been the subject of 2 granted patents and 6 additional pending patent applications to date.
Shelley Claridge于德州A&M大学获得数学与生物学双学士学位。以软件工程师的身份工作六年后，进入UC Berkeley学习并完成Ph.D学业，师从Paul Alivisatos 和 Jean Fréchet。又于UCLA师从Paul Weiss完成博士后工作，于2013年任教普渡大学，2019年晋升为Associate Professor，取得终身教职。她在普渡的研究工作颇受认可，于多个机构获得青年科学家奖 ：NSF；DARPA (Young Faculty Award, 2017; Director’s Fellowship, 2019;)； 3M；DuPont (2016年全球8人之一)。作为科研新秀，她的研究工作频频见刊于ACS Nano，Journal of the American Chemical Society， Chemical Communications，Analytical Methods, and Analytical 和 Bioanalytical Chemistry等。她的课题组工作已有两项获批专利和六项待批专利。