Micro/nano-devices for Biomedical Applications
微纳生物医学器件
Xi XIE（谢曦）
ABSRACT
Micro/nano system technology have greatly facilitate the development of bioinformatics research. In the field of bioelectronics and bioinformatics, researches have been greatly attracted by biological system modeling and disease predictions based on the understanding of intracellular protein dynamic expression. We have been focusing on the fundamental research on micro/nano-system for biomedical applications, trying to address the key issues on three levels, from the outside to the inside, in vitro – transdermal – and in vivo, aiming to overcome the key challenge of how to develop bio-safe technology to detect and regulate biological disease: 1) On the in vitro cellular level, we made breakthrough process on the development of nano-devices that could safely penetrate cell membrane, achieving regulation and sensing of the intracellular contents dynamically. 2) On the transdermal level, we systematically developed transdermal theranostic system, achieving precise and in situ detection and therapy of diseases. 3) On the in vivo level, we creatively develop bio-safe implantable theranostic system, achieving safe regulation and sensing of diseases in vivo. Our work holds great promise on facilitating the development of new tools for biomedical sensing detection and biomedical therapy, which would be critically important for the field of bioelectronics.
微电子技术与生物科学的融合交叉，极大推动了新型医学诊疗技术的发展，并已成为当前研究热点之一。现代生物电子与学研究要求在微观尺度原位实时地对细胞内部或动物体内部进行调控治疗和检测传感。但当前技术方法仍存在多个难题，其中包括： 1）如何无创或微创式调控或检测细胞内部环境；2）如何原位实时调控或检测细胞或体内的动态生物信息；3）如何实现高度生物相容性的可植入器件技术，等一系列难题。谢曦团队工作致力于新型微纳生物医学器件的基础研究，发展原位实时的治疗/检测技术方法：1）致力于研发新型微纳芯片或器件，应用于功能性细胞（免疫细胞、干细胞、癌细胞等）的基础研究，实现对细胞的精准调控或检测传感；2）研发新型的穿戴式/植入式设备，应用于重点疾病（糖尿病、心血管病、神经性疾病等）的诊疗应用，实现对疾病的精准治疗调控或检测传感。
BIOGRAPHY
Prof. Xi Xie is currently a full professor in the School of Electronics and Information Technology at Sun Yat-sen University, and is an adjunct professor in the First Affiliated Hospital of Sun Yat-sen University at the meantime. He graduated from Stanford University in USA with PhD degree on 2014, and then worked as a postdoc researcher in the Prof. Robert Langer’s lab at Massachusetts Institute of Technology. On 2016, he started his own research lab at Sun Yat-sen University. Prof. Xi Xie has been focusing on the fundamental research on micro/nano-system for biomedical applications. He has published 54 manuscripts. As corresponding author or first authors, 36 manuscripts have been published on journals including Nature Biomedical Engineering, Nature Nanotechnology, ACS Nano, Advanced Functional Materials and et al. These works were highlighted by Nature series journals for 3 times. He is also applying for more than 38 patents at the meantime. He was awarded by “MIT Technology Reviews Innovators Under 35 China”, and won the “Outstanding Scientific Award of Chinese Institute of Electronics”, and the “Microsystems & Nanoengineering Summit 2019 Young Scientist Award”. Prof. Xi Xie served as the editorial board member in two core journals including Life Science Instruments, and served as the academic members in three academic associations in China..
谢曦，在中山大学光电材料与技术国家重点实验室任正教授，作为生物电子学平台学术带头人，带领45人科研团队。他博士毕业于美国斯坦福大学，博士后在麻省理工学院Langer实验室开展研究。回国独立工作后，突破性提出“微介入传感”技术，取得3方面成绩：1）引领性提出基于微纳针头阵列的微介入传感方法论，2）在国际率先阐明了微介入传感方法的生物安全边界与器件集成可行性；3）创新性发展微针阵列安全透皮传感方法，大大提升皮下传感稳定性。发表论文54篇，一作和通讯作者论文36篇，发表于Nature Nanotechnology、Nature BME等；3次被Nature子刊亮点报导，并入选《麻省理工科技评论》中国区科技创新35人。中国电子学会也对其表彰了“优秀科技工作奖”，而中国领军SCI期刊—Microsystems & Nanoengineering则对其表彰了青年科学家奖。申请发明专利38项，软件著作8项。在《生命科学仪器》等2个核心期刊任编委；在国内3个学会任委员和理事。受邀在IEEE-3M Nano、国际生物医学信息感知与微系统大会等做特邀报告>30次。